Compound	Weighted toxic potential	wTP class	Main target	Comments
Abafungin	0.230	–		antifungal drug
Abanoquil	0.477	*		α1-adrenergic antagonist
Abecarnil	0.385	*		anxiolytic drug
Abiraterone	0.676	**	MR	under investigation for prostate cancer treatment
Abunidazole (R/S)	0.210 / 0.156	–		antifungal drug
Acaprazine	0.248	–		nootropic drug
Acemetacin	0.587	**	TRβ	treatment of arthritis: moderate toxicity, not teratogenic
Acenocoumarol (R/S)	0.162 / 0.216	–		anticoagulant
Acepromazine	0.267	–		sedative, antiemetic drug
Aceprometazine (R/S)	0.132 / 0.338	*		neuroleptic, antihistamine
Acetazolamide	0.185	–		carbonic anhydrase inhibitor: not toxic
Acetohexamide	0.168	–		treatment of diabetes mellitus type 2
Acetophenazine	0.267	–		antipsychotic
Aciclovir	0.264	–		analgesic
Adafenoxate	0.269	–		nootropic in rats
Adapalene	0.417	*		treatment of acne and pilaris keratosis
Afimoxifene	0.465	*		selective estrogen-receptor modulator
Agomelatine	0.373	*		antidepressant
Alaproclate (R/S)	0.293 / 0.296	–		antidepressant
Albendazole	0.399	*		treatment of worm infestations
Alclofenac	0.191	–		NSAID
Alclometasone	0.584	**	GR	anti-inflammatory, antipruritic, antiallergic, vasoconstrictive agent
Aldesulfone	0.187	–		treatment of leprosy
Alfadolone	0.640	**	MR	neuroactive steroid with hypnotic effects
Alfaxalone	0.373	–		general anesthetic
Alfetamine (R/S)	0.137 / 0.192	–		antidepressant (not marketed)
Alfentanil	0.079	–		analgesic drug (used as anesthesia in surgery)
Alfuzosin	0.410	*		treatment of benign prostatic hyperplasia
Alimemazine (R/S)	0.000 / 0.000	–		antipruritic drug
Alizapride	0.127	–		antiemetic drug
Allantoin (R/S)	0.102 / 0.157	–		keratolytic agent: non-toxic
Allobarbital	0.371	*		anticonvulsant
Allopurinol	0.010	–		treatment of hyperuricemia
Alminoprofen (R/S)	0.143 / 0.146	–		NSAID
Almotriptan	0.006	–		treatment of migraine headaches
Amantadine	0.035	–		antiviral and antiparkinsonian drug
Amcinonide	0.660	**	GR	corticosteroid
Amiloride	0.172	–		potassium-sparing diuretic
Aminorex (R/S)	0.021 / 0.042	–		anorectic stimulant drug
Amiodarone	0.276	–		antiarrhythmic agent
Amitraz	0.157	–		antiparasitic drug
Amlexanox	0.522	**	TRα	antiallergic, anti-inflammatory
Amodiaquine	0.063	–		antimalarial and anti-inflammatory drug
Amoxapine	0.263	–		antidepressant drug
Amsacrine	0.268	–		antineoplastic agent
Anagrelide	0.479	*		treatment of chronic myeloid leukemia
Anecortave	0.414	*		angiogenesis inhibitor
Aniracetam	0.314	*		nootropic, more potent than piracetam: some side effects
Anisindione	0.176	–		anticoagulant
Antazolin	0.301	*		antihistamine drug
Apomorphine	0.483	*		dopaminergic agonist (D1/D2)
Apraclonidine	0.042	–		treatment of glaucoma
Aprinidine	0.289	–		antiarrhythmic agent
Asenapine	0.184	–		treatment of schizophrenia
Aspirin	0.233	–		antipyretic drug
Astemizole	0.208	–		antihistamine drug
Atovaquone	0.059	–		treatment of PCP, toxoplasmosis and malaria
Azatadine	0.386	*		antihistamine
Azathioprine	0.106	–		immunosuppressant
Baclofen (R/S)	0.492 / 0.281	*		spasticity treatment
Balsalazide	0.227	–		treatment of inflammatory bowel disease
Bamipine	0.223	–		antipruritic drug
Barbital	0.234	–		first commercially marketed barbiturate
Bendazac	0.321	*		NSAID
Bendroflumethiazide (R/S)	0.292 / 0.079	–		treatment of hypertension
Bentiromide (R/S)	0.478 / 0.293	*		treatment of chronic pancreatis: withdrawn in the USA and Canada
Benzatropine (cis/trans)	0.356 / 0.158	*		treatment of drug-induced parkinsonims, akathisia and acute dystonia
Benzbromarone	0.285	–		uricosuric agent, treatment of gout
Benzocaine	0.156	–		local anesthetic
Benzoctamine	0.200	–		sedative, anxiolytic
Benzydamine	0.249	–		NSAID
Bepridil (R/S)	0.016 / 0.000	–		treatment of angina
Betahistine	0.178	–		treatment of balance disorders
Betamethasone	0.523	**	GR	anti-inflammatory, immunosuppressive drug
Betamipron	0.274	–		prevention of (panipenem-caused) nephrotoxicity
Betanidine	0.295	–		sympatholytic drug
Betaxolol (R/S)	0.175 / 0.265	–		treatment of hypertension and glaucoma
Betazole	0.234	–		H2 receptor agonist
Bevantolol (R/S)	0.281 / 0.275	–		calcium-channel blocker
Bexarotene	0.583	**	TRα	antienoplastic agent
Bezafibrate	0.379	*		treatment of hyperlipidemia
Bezitramide	0.223	–		analgesic drug
Bicifadine (RR/SS)	0.191 / 0.219	–		analgesic drug
Biclotymol	0.203	–		phenolic antiseptic
Bifonazole (R/S)	0.104 / 0.221	–		antifungal drug
Binospirone (R/S)	0.339 / 0.210	–		partial 5HT1A agonist; anxiolytic effects
Biperiden (R/S)	0.000 / 0.034	–		antiparkisonian agent
Biricodar	0.246	–		treatment of ovarian cancer
Bisacodyl	0.223	–		laxative drug
Bisoprolol (R/S)	0.154 / 0.053	–		treatment of cardiovascular diseases
Bisoxatin	0.552	**	ERα	laxative drug
Bitolterol (R/S)	0.253 / 0.308	*		treatment of asthma and COPD
Blonanserin	0.381	*		antipsychotic drug
Bopindolol (R/S)	0.313 / 0.293	*		β-blocker; acts as prodrug for pindolol
Bornaprine (R/S)	0.269 / 0.369	*		anticholinergic drug
Bosentan	0.128	–		treatment of pulmonary artery hypertension
Bretazenil	0.101	–		anxiolytic drug
Brifentanil	0.148	–		opioid analgesic
Brimonidine	0.164	–		treatment of open-angle glaucoma or ocular hypertension
Brinzolamide (R/S)	0.034 / 0.059	–		treatment of glaucoma or ocular hypertension
Brivudine	0.241	–		antiviral drug
Brodimoprim	0.298	–		antibacterial drug
Brofaromine	0.243	–		treatment of depression and anxiety
Bromazepam	0.363	*		anxiolytic drug; at higher doses sedative and hypnotic
Bromazine (R/S)	0.079 / 0.309	*		antihistamine
Bromfenac	0.466	*		NSAID
Bromhexine	0.000	–		mucolytic agent
Bromopride	0.245	–		antiemetic drug
Bromperidol	0.114	–		treatment of schizophrenia
Brompheniramine (R/S)	0.174 / 0.233	–		antihistamine
Brotizolam	0.196	–		anxiolytic, anticonvulsant, sedative
Broxaterol (R/S)	0.204 / 0.038	–		β-adrenergic agonist
Broxyquinoline	0.038	–		anti-infective agent
Bucolome	0.084	–		analgesic, anti-inflammatory
Budipine	0.247	–		dopaminergic agent
Budralazine	0.073	–		vasodilator
Bufexamac	0.348	*		anti-inflammatory, analgesic
Buflomedil	0.106	–		vasoactive drug (treatment of claudication)
Bumadizone (R/S)	0.286 / 0.158	–		NSAID
Bumetanide	0.345	*		loop diuretic: high plasma levels are toxic to animals
Bunaftine	0.230	–		antiarrhythmic agent
Bunazosin	0.150	–		α1-antagonist
Buparvaquone	0.156	–		antiprotozoal drug
Bupivacaine	0.243	–		local anesthetic
Busulfan	0.231	–		chemotherapy drug
Butaclamol	0.210	–		antipsychotic
Butalamine	0.342	*		vasodilator
Butamirate (R/S)	0.221 / 0.026	–		cough suppressant
Butaxamine	0.108	–		β2-selective blocker
Butenafine	0.042	–		antifungal agent
Butoconazole (R/S)	0.524 / 0.540	**	ERβ	antifungal agent
Butriptyline (R/S)	0.290 / 0.262	–		antidepressant
Cabergoline	0.165	–		dopamine-receptor agonist
Cadralazine (R/S)	0.090 / 0.145	–		treatment of hypertension
Cafedrine (RR/RS/SR/SS)	0.318 / 0.096 / 0.248 / 0.114	*		cardiac stimulant
Camazepam (R/S)	0.205 / 0.089	–		anxiolytic, anticonvulsant, sedative
Camostat	0.000	–		serine protease inhibitor
Canrenone	0.589	**	MR	metabolite of spironolactone
Canrenonic acid	0.317	–		canrenone derivative
Captodiame (R/S)	0.349 / 0.087	*		anxiolytic drug
Captopril	0.140	–		treatment of hypertension
Carazolol (R/S)	0.364 / 0.243	*		anxiolytic, anticonvulsant, sedative
Carbamazepine	0.222	–		anticonvulsant
Carbazochrome (R/S)	0.249 / 0.193	–		antihemorrhagic agent
Carbenoxolone	0.000	–		treatment of inflammation
Carbidopa	0.052	–		treatment of Parkinson's disease
Carbimazole	0.003	–		treatment of hyperthroidism
Carbinoxamine (R/S)	0.000 / 0.148	–		antihistamine
Carboquone (R/S)	0.152 / 0.027	–		chemotherapeutic agent
Carbocromen	0.079	–		vasodilator
Carbutamide	0.230	–		anti-diabetic drug
Carbuterol (R/S)	0.081 / 0.232	–		β2-agonist
Carfentanyl	0.269	–		opioid analgesic
Carisoprodol (R/S)	0.129 / 0.165	–		muscle relaxant
Carmofur	0.216	–		antienoplastic agent
Caroverine	0.382	*		treatment of gastrointestinal disorders
Carperidine	0.231	–		opioid analgesic
Carprofen (R/S)	0.329 / 0.362	*		NSAID used by veterinarians
Carteolol (R/S)	0.251 / 0.287	–		treatment of glaucoma
Celiprolol (R/S)	0.184 / 0.000	–		antihypertensive
Centrophenoxine	0.241	–		nootropic (senile dementia, Alzheimer): some side effects
Cetiedil (R/S)	0.326 / 0.205	*		vasodilator
Cetraxate	0.142	–		cytoprotective agent
Cevimeline	0.056	–		parasympathomimetic
Chiniofon	0.060	–		antiprotozoal agent
Chlorambucil	0.364	*		chemotherapeutic drug
Chlorbenzoxamine (R/S)	0.286 / 0.280	–		treatment of gastrointestinal disorders
Chlorcyclizine (R/S)	0.231 / 0.232	–		antihistamine
Chlormadinone	0.361	*		proestrogen (added to contraceptives)
Chlormezanone (R/S)	0.126 / 0.347	*		anxiolytic
Chloropyramine	0.313	*		first-generation antihistamine
Chloroquine (R/S)	0.125 / 0.256	–		treatment and prevention of malaria
Chlorothen	0.280	–		antihistamine
Chlorothiazide	0.053	–		diuretic, antihypertensive
Chlorotrianisene	0.711	***	ERα	synthetic estrogen
Chlorphenamine (R/S)	0.137 / 0.260	–		first-generation antihistamine
Chlorphenesin (R/S)	0.296 / 0.364	*		muscle relaxant
Chlorphenoxamine (R/S)	0.221 / 0.098	–		antipruritic
Chlorpromazine	0.358	*		treatment of schizophrenia
Chlorpropamide	0.268	–		treatment of type-2 diabetes
Chlorprothixene	0.312	*		antipsychotic drug
Chlorzoxazone	0.277	–		muscle relaxant
Ciclazindol (R/S)	0.248 / 0.342	*		antidepressant
Ciclesonide	0.412	*		treatment of obstructive airway diseases
Cicletanine (R/S)	0.131 / 0.227	–		low-ceiling diuretic drug
Ciclobendazole	0.300	–		antihelmintic drug
Ciclonicate	0.297	–		vasodilating agent
Ciclopirox	0.259	–		antifungal agent
Cilansetron	0.293	–		5HT3 antagonist
Cilnidipine	0.388	*		5HT3 antagonist
Cilostazol	0.461	*		treatment of intermittent claudication
Cimetidine	0.106	–		H2-receptor antagonist
Cimoxatone (R/S)	0.450 / 0.390	*		antidepressant
Cinacalcet	0.375	*		calcimimetic
Cinanserin	0.491	*		serotonin receptor antagonist
Cinchocaine	0.160	–		local anesthetic
Cinchophen	0.226	–		analgesic drug
Cinnarizine (cis/trans)	0.235 / 0.477	*		treatment of motion sickness
Cinolazepam (R/S)	0.207 / 0.150	–		anxiolytic, anticonvulsant, sedative
Cipemastat	0.270	–		anti-arthritis agent
Ciramadol	0.097	–		opioid analgesic
Cirazoline	0.154	–		α-adrenergic receptor agonist
Clamoxyquine	0.120	–		antiamoebic, antidhiarrheal drug
Clebopride	0.396	*		antiemetic drug
Clefamide	0.215	–		antiprotozoal agent
Clemastine	0.368	*		antihistamine
Clemizole	0.029	–		antihistamine
Clenbuterol (R/S)	0.220 / 0.184	–		bronchodilator, decongestant
Clentiazem (R/S)	0.196 / 0.276	–		calcium-channel blocker
Clevidipine	0.221	–		calcium-channel blocker
Climazolam	0.379	*		anesthetic in veterinary medicine
Clioquinol	0.060	–		antifungal and antiprotozoal drug
Clobazam	0.388	*		anxiolytic drug
Clobenzorex (R/S)	0.164 / 0.212	–		appetite suppressor (anorectic)
Clobetasol	0.506	**	GR	treatment of eczema and psoriasis
Clobetasone	0.437	*		treatment of eczema
Clobutinol (RR/RS/SR/SS)	0.135 / 0.171 / 0.281 / 0.071	–		cough suppressant
Clocinizine (R/S)	0.443 / 0.385	*		antihistamine
Clodantoin (RR/RS/SR/SS)	0.138 / 0.017 / 0.111 / 0.114	–		drug used in gynecology
Clofazimine	0.494	*		treatment of leprosy
Clofedanol (R/S)	0.199 / 0.089	–		cough suppressant
Clofenciclan	0.022	–		stimulant drug
Clofibrate	0.062	–		lipid-lowering agent
Clomethiazole	0.012	–		sedative, hypnotic
Clomifene (E/Z)	0.419 / 0.437	*		selective estrogen receptor modulator
Clominorex (R/S)	0.199 / 0.280	–		appetite suppressant
Clonazepam	0.460	*		anticonvulsant, anxiolytic
Clonidine	0.210	–		antihypertensive
Clonitazene	0.343	*		opioid analgesic
Cloperastine (R/S)	0.241 / 0.167	–		cough suppressant
Clopenthixol (cis/trans)	0.342 / 0.293	*		antipsychotic drug
Clorazepate (R/S)	0.484 / 0.360	*		anxiolytic, anticonvulsant, sedative
Clorexolone	0.406	*		low-ceiling sulfonamide diuretic
Clorgiline	0.078	–		antidepressant
Cloricromen	0.304	*		platelet-aggregation inhibitor
Cloridarol (R/S)	0.208 / 0.235	–		vasodilator
Clorindione	0.185	–		vitamin K antagonist
Cloroqualone	0.400	*		sedative, antitussive
Clotrimazole	0.284	–		sedative, antitussive
Cloxazolam (R/S)	0.440 / 0.551	**	PR	anxiolytic, anticonvulsant, sedative
Clozapine	0.205	–		antifungal medication
CNQX (6-cyano-7-nitroquinoxaline-2,3,-dione)	0.193	–		AMPA/kainate receptor antagonist
Coluracetam	0.243	–		treatment of ischemic retinopathy: little or no toxicity
Cortisol	0.437	*		steroid hormone: treatment of allergies and inflammation
Cortisone	0.629	**	ERα	steroid hormone: suppression of the immune system
Cortivazol	0.257	–		glucocorticoid receptor agonist
Croconazole	0.548	**	PR	antifungal agent
Cromoglicic acid	0.172	–		mast-cell stabilizer
Crotamiton	0.247	–		antipruritic
Cyclandelate (R/S)	0.438 / 0.170	*		vasodilator
Cyclazodone (R/S)	0.158 / 0.180	–		stimulant drug
Cyclizine	0.246	–		antihistamine
Cyclobenzaprine	0.145	–		antidepressant
Cyclofenil	0.347	*		estrogen receptor modulator
Cycloguanil	0.091	–		antimalarial drug
Cyclomethycaine	0.292	–		local anesthetic
Cyclopentolate (R/S)	0.012 / 0.210	–		mydriatic and cycloplegic agent
Cypenamine (1R,2S/1S,2R)	0.196 / 0.120	–		stimulant drug
Cyprazepam	0.185	–		benzodiazepin (not approved for sale in the US)
Cyproheptadine	0.406	*		antihistamine
Cyproterone	0.421	*		antiandrogen (treatment of precocious puberty)
Dacemazine	0.220	–		antispasmodic, antitussive
Dantrolene	0.612	**	ERα	muscle relaxant
Dapiprazole	0.211	–		mydriasis-reversing agent
Dapoxetine	0.469	*		short-acting SSRI drug
Dapsone	0.134	–		treatment of leprae
Darifenacin	0.439	*		treatment of urinary incontinence
Darodipine	0.300	–		calcium channel blocker
Darunavir	0.145	–		treatment of HIV infection
Daunorubicin	0.166	–		treatment of acute myeloid and lymphocytic leukemia
Decoquinate	0.176	–		coccidiostatic agent
Deferasirox	0.346	*		treatment of thalassaemia major
Deferiprone	0.162	–		rationally-designed iron chelator
Dehydroepiandrosterone	0.593	**	ERβ	cholesterol metabolite: liver tumor inducer
Delapril	0.223	–		ACE inhibitor
Delavirdine	0.179	–		reverse transcriptase inhibitor
Demecolcine	0.253	–		chemotherapeutic agent
Denopamine	0.227	–		treatment of angina
Deptropine	0.410	*		antihistamine with anticholinergic properties
Deracoxib	0.279	–		NSAID
Desloratadine	0.372	*		treatment of allergies
Desogestrel	0.578	**	PR	used in hormonal contraceptives
Desomorphine	0.172	–		opiate analogue
Desonide	0.468	*		treatment of eczema and dermatitis
Desoximetasone	0.423	*		psychoactive drug
Desoxipipradrol	0.113	–		treatment of various skin conditions (rashes, itching, redness)
Detomidine	0.192	–		large-animal sedative primarily used in horses
Devapamil (R/S)	0.293 / 0.237	–		calcium channel blocker
Devazepide	0.213	–		treatment of dyspepsia, gastroparesis and gastric reflux
Dexamethasone	0.539	**	GR	anti-inflammatory, immunosuppressant drug
Dexbrompheniramine	0.287	–		antihistamine
Dexfenfluramine	0.236	–		anorectic drug
Dexibuprofen	0.124	–		NSAID
Dexketoprofen	0.317	*		NSAID
Dexmedetomidine	0.122	–		sedative medication
Dexmethylphenidate	0.119	–		treatment of ADHD
Dexrazoxane	0.344	*		protection against cardiotoxic side effects of anthracyclines
Dextromoramide (R/S)	0.331 / 0.290	*		opioid analgesic
Dextromethorphan	0.192	–		antitussive drug
Dezocine	0.204	–		opioid analgesic
Diacerein	0.286	–		treatment of osteoarthritis
Diampromide (R/S)	0.328 / 0.000	*		opioid analgesic
Diazepam	0.365	*		anxiolytic, anticonvulsant, sedative
Diazoxide	0.115	–		treatment of hypertension and insulinoma
Dibenzepin	0.339	*		antidepressant
Dibrompropamidine	0.402	*		antiseptic, disinfectant
Dibunate	0.169	–		cough suppressant
Diclazuril (R/S)	0.555 / 0.622	**	PR / ERα	cocciodiostat
Diclofenac	0.307	*		analgesic: some side effects
Dicoumarol	0.327	*		anticoagulant (Vitamin K antagonist)
Dicycloverine	0.363	*		anticholinergic drug
Didanosine	0.245	–		reverse transcriptase inhibitor
Dienestrol	0.591	**	ERα	treatment of vulvar atrophy and atrophic vaginitis
Dienogest	0.597	**	PR	oral contraceptive
Diethylcarbamazine	0.064	–		antihelmintic drug
Diethylthiambutene (R/S)	0.044 / 0.177	–		opioid analgesic
Difemerine	0.285	–		antimuscarinic
Difenoxin	0.400	*		opioid analgesic
Diflunisal	0.572	**	TRβ	generic NSAID
Dihydrocodeine	0.158	–		opioid analgesic
Dihydroxyphenylglycine (DHPG)	0.290	–		mGluRS agonist
Diisopromine	0.163	–		neutralizes spastic conditions of the biliary tract
Diloxanide furoate	0.341	*		antiprotozoal drug
Diltiazem	0.195	–		treatment of hypertension, angina pectoris
Dimefline	0.091	–		respiratory stimulant
Dimethoxanate	0.180	–		cough suppressant
Diminazene	0.135	–		treatment of Trypanosmiasis
Diphenhydramine	0.309	*		antihistamine, antiemetic, sedative, hypnotic
Diphenylpyraline	0.269	–		antihistamine with psychostimulant properties
Dipivefrine (R/S)	0.066 / 0.115	–		treatment of glaucoma
Diproqualone (R/S)	0.259 / 0.244	–		sedative, anxiolytic, analgesic
Dipyramide (R/S)	0.270 / 0.127	–		antiarrhythmic medication
Disopyridamole	0.136	–		inhibits thrombus formation
Ditazole	0.541	**	ERα	platelet-aggregation inhibitor
Dithranol	0.348	*		treatment of psoriasis
Dizocilpine	0.200	–		anticonvulsant
Dobutamine (R/S)	0.353 / 0.098	*		treatment of heart failure and cardiogenic shock
Dofetilide	0.000	–		class III antiarrhythmic agent
Dolasetron	0.173	–		treatment of nausea/vomiting following chemotherapy
Domperidone	0.158	–		antidopaminergic drug
Dorzolamide (R/S)	0.029 / 0.068	–		treatment of glaucoma, ocular hypertension
Dosulepin	0.340	*		antidepressant
Dotarizine	0.446	*		vasodilator
Doxazosin (R/S)	0.517 / 0.430	**	GR	treatment of hypertension
Doxefazepam (R/S)	0.546 / 0.464	**	ERα	anxiolytic, anticonvulsant, sedative
Doxofylline	0.123	–		treatment of asthma
Doxylamine (R/S)	0.051 / 0.000	–		short-term sedative
Dronedarone	0.245	–		treatment of cardiac arrhythmias
Droperidol	0.474	*		antiemetic, antipsychotic
Dropropizine (R/S)	0.505 / 0.549	**	ERα	cough suppressant
Drospirenone	0.628	**	PR	oral contraceptive
Drotaverine	0.327	*		antispasmodic drug
Drotebanol	0.144	–		cough suppressant
Droxicam	0.234	–		NSAID
Droxypropine	0.149	–		cough suppressant
Dutasteride	0.189	–		treatment of benign prostatic hyperplasia
Dyclonine	0.390	*		oral anesthetic (throat lozenges)
Dydrogesterone	0.535	**	PR	progesterone hormone
Ebastine	0.403	*		antihistamine
Econazole (R/S)	0.378/ 0.377	*		antifungal medication
Efaroxan (R/S)	0.276 / 0.108	–		&alpha2-blocker
Eflornithine	0.292	–		treatment of African trypanosomiasis
Efloxate	0.476	*		vasodilator
Efonidipine (R/S)	0.265 / 0.221	–		calcium channel blocker
Elesclomol	0.173	–		chemotherapy adjuvant
Eletriptan	0.342	*		treatment of migraine headaches
Elfazepam	0.238	–		sedative, anxiolytic
Eliprodil (R/S)	0.004 / 0.299	–		neuroprotective, anticonvulsant
Ellipticine	0.260	–		anticancer drug
Eltrombopag	0.198	–		treatment of thrombocytopenia
Embramine (R/S)	0.130 / 0.025	–		antihistamine
Embutramide	0.470	*		sedative drug
Emedastine	0.073	–		antihistamine
Emopamil (R/S)	0.237 / 0.233	–		calcium channel blocker
Enadoline	0.257	–		selective κ-opioid agonist
Enalaprilate	0.393	*		treatment of hypertension
Encainide (R/S)	0.309 / 0.267	–		antiarrhythmic agent
Endralazine	0.018	–		treatment of hypertension
Enoximone	0.298	–		treatment of congestive heart failure
Ensaculin	0.362	*		treatment of dementia
Entacapone	0.057	–		treatment of Parkinson's disease
Entecavir	0.474	*		treatment of hepatitis B
Epalrestat	0.600	**	TRβ	treatment of diabetic neuropathy
Eperisone (R/S)	0.190 / 0.164	–		antispasmodic drug
Epinastine (R/S)	0.360 / 0.272	*		antihistamine
Epirizole	0.257	–		NSAID
Epirubicin	0.253	–		chemotherapeutic drug
Eplerenone	0.527	**	MR	treatment of chronic heart failure
Eprosartan (cis/trans)	0.497 / 0.311	*		treatment of high blood pressure
Eprazinone (RR/RS/SR/SS)	0.222 / 0.239 / 0.060 / 0.067	–		mucolytic drug
Erdosteine (R/S)	0.316 / 0.145	*		mucolytic drug
Ergonovine	0.656	**	ERβ	medical use in obstetrics
Esmolol (R/S)	0.225 / 0.237	–		β1-receptor blocker
Estazolam	0.398	*		anxiolytic, anticonvulsant, sedative
Estramustine	0.313	*		treatment of prostate cancer
Estrone sulfate	0.348	*		sulfated estrone (estrogenic hormone)
Etacrynic acid	0.163	–		loop diuretic
Etafedrine (RR/RS/SR/SS)	0.004 / 0.176 / 0.000 / 0.000	–		bronchodilator
Etafenone	0.375	*		vasodilator
Etamivan	0.439	*		respiratory stimulant
Etaqualone	0.352	*		sedative and hypnotic properties
Etazolate	0.359	*		anxiolytic drug
Ethadione	0.029	–		anticonvulsant
Ethenzamide	0.211	–		analgesic, NSAID
Ethinamate	0.131	–		sedative-hypnotic medication
Ethinylestradiol	0.790	***	ERα	oral contraceptive
Ethisterone	0.718	***	PR	progestogen hormone
Ethoheptazine (R/S)	0.301 / 0.266	*		opioid analgesic
Ethosuximide (R/S)	0.132 / 0.151	–		anticonvulsant
Ethotoin (R/S)	0.112 / 0.111	–		anticonvulsant
Ethoxzolamide	0.639	**	ERα	treatment of glaucoma
Ethylbiscoumacetate	0.160	–		vitamin K antagonist
Ethylloflazepate (R/S)	0.326 / 0.307	*		anxiolytic, anticonvulsant, sedative
Eticyclidine	0.032	–		anesthetic, hallucinogenic
Etidocaine (R/S)	0.068 / 0.159	–		local anesthetic
Etifoxine (R/S)	0.447 / 0.298	*		anxiolytic, anticonvulsant
Etilefrine (R/S)	0.136 / 0.243	–		cardiac stimulant
Etiracetam (R/S)	0.003 / 0.001	–		nootropic: mild side effects
Etizolam	0.266	–		amnesic, anxiolytic, anticonvulsant, hypnotic, sedative
Etodolac (R/S)	0.242 / 0.258	–		NSAID
Etofamide	0.315	*		antiprotozoal drug
Etofenamate	0.491	*		treatment of joint and muscular pain
Etofibrate	0.105	–		hybrid drug: clofibrate and niacin
Etomidate	0.154	–		general anesthetic, sedative
Etonitazene	0.369	*		analgesic
Etonogestrel	0.659	**	ERβ	hormonal contraceptive
Etoperidone	0.244	–		antidepressant
Etoricoxib	0.242	–		COX-2 selective inhibitor
Etoxadrol	0.238	–		dissociative anesthetic
Etravirine	0.205	–		treatment of HIV
Etretinate	0.547	**	GR	treatment of severe psioriasis
Etybenzatropine	0.237	–		treatment of Parkinson's disease
Etymemazine (R/S)	0.000 / 0.000	–		antihistamine
Eupatilin	0.547	**	MR	treatment of acid-related disorders
Exemestane	0.532	**	ERα	treatment of breast cancer
Fadrozole (R/S)	0.187 / 0.197	–		treatment of breast cancer
Falipamil	0.239	–		calcium channel blocker
Famciclovir	0.196	–		antiviral drug
Famotidine	0.361	*		treatment of peptic ulcer disease
Fananserin	0.058	–		sedative, antipsychotic
Fasoracetam (R/S)	0.242 / 0.369	*		nootropic
Fasudil	0.243	–		treatment of cerebral vasospasm
Febuxostat	0.300	–		treatment of hyperuricemia
Fedrilate (R/S)	0.472 / 0.499	*		cough suppressant
Felbamate	0.147	–		anticonvulsant
Felbinac	0.148	–		NSAID
Felodipine	0.434	*		calcium channel blocker
Femoxetine	0.377	*		antidepressant
Fenbendazole	0.148	–		anthelmintic agent
Fenbufen	0.511	**	TRβ	NSAID
Fendiline (R/S)	0.313 / 0.378	*		calcium channel blocker
Fenethylline (R/S)	0.222 / 0.282	–		stimulant drug
Fenobam	0.147	–		anxiolytic drug
Fenoldopam (R/S)	0.184 / 0.173	–		dopamine D1A receptor agonist
Fenoprofen (R/S)	0.223/ 0.105	–		NSAID
Fenoterol (RR/RS/SR/SS)	0.205 / 0.197 / 0.176 / 0.203	–		asthma medication
Fenoverine	0.375	*		antispasmodic drug
Fenozolone (R/S)	0.131 / 0.323	*		stimulant drug
Fenoxazoline	0.136	–		nasal preparation
Fenpiprane	0.291	–		treatment of gastrointestinal disorders
Fenproporex (R/S)	0.137 / 0.027	–		appetite suppressant
Fenquizone (R/S)	0.231 / 0.294	–		diuretic
Fenretinide	0.336	*		treatment of cancer, cystic fibrosis, arthritis, acne, psoriasis
Fenspiride	0.269	–		treatment of certain respiratory diseases
Fentanyl	0.162	–		opioid analgesic
Fentiazac	0.331	*		treatment of joint and muscular pain
Fenticonazole (R/S)	0.560 / 0.388	**	ERα	antifungal drug
Feprazone	0.314	*		treatment of joint and muscular pain
Fexofenadine (R/S)	0.177 / 0.312	*		antihistamine
Finasteride	0.581	**	AR	antiandrogen: birth defects, depression
Fipexide	0.407	*		nootropic (senile dementia): adverse reactions, out of use
Flavoxate	0.417	*		anticholinergic drug; muscle relaxant
Flecainide	0.443	*		antiarryhthmic agent
Fleroxacin	0.175	–		antibacterial drug
Flesinoxan	0.344	*		anxiolytic drug
Fletazepam	0.251	–		sedative, anxiolytic
Flibanserin	0.487	–		antidepressant; lifestyle drug
Flopropione	0.293	–		antispasmodic drug
Florantyrone	0.561	**	TRα	treatment of biliary dyskinesia
Florfenicol	0.118	–		treatment of bovine respiratory disease
Flosequinan	0.120	–		vasodilator
Fluacizine	0.000	–		antidepressant
Flubendazole	0.404	*		anthelmintic
Fluconazole	0.179	–		antifungal drug
Fludiazepam	0.376	*		anxiolytic, anticonvulsant, sedative
Fludorex (R/S)	0.178 / 0.144	–		appetite suppressant
Fludrocortisone	0.457	*		synthetic corticosteroid
Fludroxycortide	0.576	*	MR	synthetic steroid (anti-inflammatory drug)
Flufenamic acid	0.356	*		NSAID
Fluindione	0.202	–		vitamin K antagonist
Flumazenil	0.264	–		benzodiazepine antidote
Flumedroxone	0.392	*		corticosteroid (treatment of migraine)
Flumetasone	0.432	*		corticosteroid (treatment of otitis externa)
Fluminorex (R/S)	0.153 / 0.150	–		appetite suppressant
Flunarizine	0.468	*		prophylaxis of migraine
Flunisolide	0.503	**	GR	corticosteroid (treatment of allergic rhinitis)
Flunixin	0.521	**	MR	NSAID
Flunoxaprofen	0.428	*		NSAID
Fluocortin	0.221	–		corticosteroid
Fluocortolone	0.356	*		glucocorticoid (treatment of hemorrhoids)
Fluorometholone	0.456	*		corticosteroid (used after laser-based refractive surgery)
Fluorouracil	0.206	–		antimetabolite (cancer treatment)
Flupentixol (E/Z)	0.346 / 0.209	*		antipsychotic drug
Fluphenazine	0.392	*		antipsychotic drug
Flupirtine	0.312	*		analgesic
Fluproquazone	0.395	*		analgesic, antipyretic, anti-inflammatory
Flurbiprofen (R/S)	0.252 / 0.215	–		NSAID
Fluspirilene	0.092	–		treatment of schizophrenia
Flutamide	0.134	–		antiandrogen, treatment of prostate cancer
Flutazolam (R/S)	0.383 / 0.390	*		sedative, muscle relaxant, anticonvulsant, anxiolytic
Flutemazepam (R/S)	0.443 / 0.449	*		sedative, anxiolytic
Flutoprazepam	0.286	–		sedative, hypnotic, anxiolytic, anticonvulsant
Flutrimazole (R/S)	0.314 / 0.333	*		antifungal agent
Folinic acid (RR/SR)	0.217 / 0.007	–		adjuvant used in cancer chemotherapy
Formestane	0.487	*		treatment of breast cancer
Forodesine	0.080	–		treatment of chronic lymphocytic leukemia
Fosazepam	0.369	*		sedative, anxiolytic
Fosfestrol	0.000	–		antienoplastic agent
Fosinopril	0.178	–		treatment of hypertension
Fosphenytoin	0.080	–		treatment of epileptic seizures
Frovatriptan	0.248	–		treatment of migraine headaches
Furethidine (R/S)	0.284 / 0.201	–		opioid analgesic
Furfenorex (R/S)	0.000 / 0.044	*		appetite suppressant
Furosemide	0.116	–		loop diuretic: renal toxicity in rats
Gabapentin	0.179	–		treatment of epilepsy
Gabexate	0.157	–		treatment of pancreatitis
Gaboxadol	0.198	–		experimental sleeping pill
Gacyclidine	0.000	–		neuroprotective agent
Galantamine	0.307	*		treatment of Alzheimer's disease: gastrointestinal syndromes
Gallamine	0.000	–		muscle relaxant
Gallopamil (R/S)	0.214 / 0.093	–		calcium channel blocker
Ganaxolone	0.631	**	AR	sedative, anxiolytic, anticonvulsant
Ganciclovir	0.291	–		antiviral drug
Gapicomine	0.113	–		coronary vasodilator
Gedocarnil	0.361	*		anxiolytic drug
Gefitinib	0.401	*		treatment of certain types of cancer
Gemfibrozil	0.308	*		lipid-level lowering drug
Gepefrine (R/S)	0.160 / 0.080	–		cardiac stimulant
Gestodene	0.662	**	PR	hormonal contraceptive
Gilutensin	0.330	*		treatment of hypotension
Girisopam	0.507	**	AhR	anxiolytic drug
Glibenclamide	0.000	–		antidiabetic drug
Glimepiride	0.001	–		antidiabetic drug
Glipizide	0.000	–		antidiabetic drug
Gliquidone	0.051	–		antidiabetic drug
Glutethimide (R/S)	0.360 / 0.217	*		hypnotic sedative
Glyclopyramide	0.131	–		antidiabetic drug
Granisetron	0.186	–		treatment of nausea and vomiting following chemotherapy
Griseofulvin	0.224	–		antifungal drug
Guaifenesin (R/S)	0.295 / 0.278	–		expectorant drug
Guanadrel (R/S)	0.243 / 0.275	–		antihypertensive agent
Guanabenz	0.186	–		antihypertensive drug
Guanoxan (R/S)	0.163 / 0.194	–		sympatholytic drug
Halazepam	0.266	–		anxiolytic, anticonvulsant, sedative, muscle relaxant
Halcinonide	0.614	**	GR	corticosteroid (treatment of certain skin conditions)
Halofantrine (R/S)	0.469 / 0.392	*		treatment of malaria
Halofuginone	0.192	–		coccidiostat
Halometasone	0.542	**	GR	corticosteroid
Haloperidol	0.335	*		treatment of schizophrenia
Haloprogin	0.255	–		treatment of athlete's foot and other fungal infections
Haloxazolam (R/S)	0.309 / 0.239	*		anxiolytic
Hexacyclonate	0.152	–		treatment of hyperlipoproteinemia
Hexapropymate	0.202	–		hypnotic/sedative drug
Hexobarbital (R/S)	0.287 / 0.086	–		hypnotic/sedative agent
Hexylcaine (R/S)	0.386 / 0.351	*		local anesthetic
Histapyrrodine	0.356	*		antihistamine with anticholinergic properties
Homochlorcyclizine (R/S)	0.297 / 0.220	–		antiallergic drug
Huperzine A	0.172	–		neuroprotective effects: low toxicity
Hycanthone	0.202	–		schistosomicide
Hydralazine	0.198	–		vasodilator
Hydrochlorothiazide	0.209	–		diuretic drug
Hydrocodone	0.189	–		semi-synthetic opioid
Hydroflumethiazide	0.219	–		diuretic
Hydromorphinol	0.154	–		morphine derivative (sedative, analgesic)
Hydroxychloroquine (R/S)	0.125 / 0.191	–		antimalarial drug
Hydroxydione	0.733	***	ERα	general anesthetic
Hydroxypethidine	0.253	–		opioid analgesic
Hydroxyurea	0.005	–		antienoplastic drug
Hydroxyzine (R/S)	0.338 / 0.596	**	ERβ	first-generation antihistamine
Hymecromone	0.346	*		used in bile therapy
Ibopamine	0.181	–		sympathomimetic
Ibudilast	0.200	–		anti-inflammatory drug
Ibuprofen (R/S)	0.154/ 0.181	–		NSAID; treatment of arthritis, fewer
Ibuproxam (R/S)	0.420 / 0.343	*		NSAID
Iclaprim (R/S)	0.318 / 0.280	–		treatment of skin and tissue infections
Iclazepam	0.247	–		sedative, anxiolytic
Idazoxan (R/S)	0.107 / 0.135	–		antidepressant (not marketed)
Idoxuridine	0.308	*		antiviral drug
Ifenprodil (RR/RS/SR/SS)	0.281 / 0.367 / 0.342 / 0.235	–		selective inhibitor of the NMDA receptor
Iloperidone	0.160	–		investigational antipsychotic
Imatinib	0.000	–		treatment of CML and GISTs: various side effects
Imidafenacin	0.361	–		urinary antispasmodic
Imidapril	0.030	–		antihypertensive
Imiquimod	0.256	–		immune-response modifier
Imolamine	0.315	*		vasodilator
Impromidine	0.144	–		histamine H2 receptor agonist
Imuracetam	0.084	–		nootropic drug
Inamrinone	0.263	–		treatment of congestive heart failure
Indanorex (R/S)	0.237 / 0.166	–		appetite suppressant
Indapamide (R/S)	0.355 / 0.226	*		diuretic
Indatraline	0.307	*		monoamine reuptake inhibitor
Indecainide	0.312	*		antiarrhythmic agent
Indeloxazine	0.293	–		antidepressant, anticonvulsant
Indinavir	0.000	–		treatment of HIV infection and AIDS
Indobufen (R/S)	0.451 / 0.400	*		platelet aggregation inhibitor
Indomethazine	0.421	*		NSAID
Indoprofen (R/S)	0.260 / 0.457	*		NSAID
Indoramin	0.169	–		α-1 selective adrenoreceptor antagonist
Iprazochrome (R/S)	0.145 / 0.212	–		antimigraine agent
Ipriflavone	0.395	*		prevention of osteoporosis
Iprindole	0.333	*		antidepressant
Iproclozide	0.119	–		antidepressant
Iproniazid	0.092	–		antidepressant
Ipsapirone	0.182	–		anxiolytic
Irinotecan	0.000	–		treatment of colon cancer
Isavuconazole	0.207	–		antifungal drug
Isoaminile (RR/RS/SR/SS)	0.220 / 0.142 / 0.173 / 0.277	–		cough suppressant
Isobromindione	0.281	–		treatment of gout
Isocarboxazid	0.061	–		treatment of resistant depression
Isoconazole (R/S)	0.262 / 0.463	*		antifungal drug
Isoetarine (RR/RS/SR/SS)	0.128 / 0.122 / 0.000 / 0.010	–		β2-receptor antagonist
Isoprenaline (R/S)	0.172 / 0.109	–		sympathomimetic
Isosorbide mononitrate	0.318	*		treatment of angina pectoris
Isothipendyl (R/S)	0.066 / 0.012	–		antipruritic drug
Isotretinoin	0.577	**	TRα	retinoid; treatment of severe acne
Ispronicline	0.314	*		treatment of dementia and Alzheimer's disease: well tolerated
Isradipine	0.212	–		treatment of high blood pressure
Istradefylline	0.422	*		treatment of Parkinson's disease
Itopride	0.437	*		treatment of functional dispepsia
Ivabradine	0.476	*		antianginal drug
Kebuzone	0.182	–		NSAID
Ketamine (R/S)	0.033 / 0.131	–		analgesic, anesthetic
Ketanserin	0.004	–		antihypertensive
Ketazolam (R/S)	0.279 / 0.218	–		anxiolytic, anticonvulsant, sedative, muscle relaxant
Ketobemidone	0.172	–		treatment of severe pain
Ketoconazole	0.463	*		antifungal drug
Ketoprofen (R/S)	0.372 / 0.271	*		NSAID
Ketorolac (R/S)	0.341 / 0.380	*		NSAID
15-Ketosterol	0.323	*		potential anti-atherosclerotic agent
Ketotifen	0.422	*		treatment of allergic reactions; prevention of asthma attacks
Lamotrigine	0.254	–		anticonvulsant drug
Latanoprost	0.374	*		treatment of glaucoma, ocular hypertension
Lefetamine	0.148	–		psychoactive drug (stimulant and analgesic)
Leflunomide	0.205	–		treatment of rheumatoid and psoriatic arthritis
Lerisetron	0.334	*		antinauseant
Letrozole	0.214	–		treatment of hormonally-responsive breast cancer
Levallorphan	0.313	*		general anesthetic
Levetiracetam	0.041	–		treatment of epilepsy
Levobunolol (S)	0.295	*		beta blocker, treatment of glaucoma
Levobupivacaine	0.251	–		local anesthetic
Levocabastine	0.000	–		treatment of allergic conjunctivitis
Levocetirizine	0.582	**	TRα	non-sedative antihistamine
Levodropropizine	0.524	**	ERα	cough suppressant
Levomepromazine	0.202	–		neuroleptic drug
Levonantradol	0.318	*		antiemetic, analgesic
Levonordefrin	0.077	–		topical nasal decongestant
Levonorgestrel	0.603	**	PR	hormonal contraceptive
Levorphanol	0.171	–		opioid medication: treatment of severe pain
Levosimendan	0.570	**	MR	treatment of congestive heart failure
Levothyroxine	0.102	–		treatment of hyperthyroidism
Lidocaine	0.000	–		local anesthetic
Lidoflazine	0.000	–		calcium channel blocker
Linopirdine	0.390	*		psychostimulant, nootropic
Liothyronine	0.380	*		thyroid hormone: various side effects
Lisinopril	0.048	–		treatment of hypertension, congestive heart failure
Lobenzarit	0.331	*		treatment of arthritis
Lofendazam	0.440	*		sedative, anxiolytic
Lofentanil	0.075	–		opioid analgesic
Lofexidine (R/S)	0.275 / 0.098	–		short-acting antihypertensive
Lomerizine	0.370	*		treatment of migraine
Lomustine	0.034	–		chemotherapeutic agent
Lonazolac	0.446	*		NSAID
Lonidamine	0.447	*		chemotherapeutic agent
Loperamide	0.106	–		treatment of diarrhea
Lopirazepam (R/S)	0.257 / 0.148	–		anxiolytic, hypnotic properties (never marketed)
Loprazolam	0.243	–		anxiolytic, anticonvulsant, sedative, muscle relaxant
Loratadine	0.557	**	ERα	antiallergic, non-sedating
Lorcainide	0.390	*		antiarrhythmic agent
Loreclezole	0.311	*		sedative, anticonvulsant
Lornoxicam	0.237	–		NSAID
Losartan	0.150	–		treatment of hypertension
Loviride (R/S)	0.360 / 0.384	*		treatment of HIV
Loxapine	0.127	–		treatment of schizophrenia
Loxoprofen (RR/RS/SR/SS)	0.269 / 0.352 / 0.212 / 0.264	*		NSAID
Lubeluzole (R/S)	0.000 / 0.092	–		treatment of stroke
Lumefantrine (RE/RZ/SE/SZ)	0.000 / 0.000 / 0.272 / 0.376	*		antimalarial drug
Lurosetron	0.350	*		serotonin 5-HT3 receptor antagonist
Mabuterol (R/S)	0.268 / 0.189	–		β-adrenergic agonist
Malotilate	0.289	–		treatment of liver disease
Manidipine	0.156	–		calcium channel blocker
Maprotiline	0.304	*		antidepressant drug
Masoprocol	0.438	*		antienoplastic drug
Mazindol (R/S)	0.116 / 0.190	–		CNS stimulant
Mebendazole	0.347	*		treatment of worm infestations
Mebeverine (R/S)	0.453 / 0.315	*		antispasmodic drug
Mebhydrolin	0.288	–		antihistamine
Mebutamate (R/S)	0.113 / 0.031	–		sedative, anxiolytic with antihypertensive effects
Mecamylamine	0.116	–		treatment of hypertension
Meclizine (R/S)	0.328 / 0.127	–		antihistamine
Meclofenamic acid	0.386	*		treatment of joint and muscular pain
Meclonazepam	0.179	–		sedative, anxiolytic
Mecloqualone	0.463	*		sedative, hypnotic, anxiolytic
Medazepam	0.107	–		anxiolytic, anticonvulsant, sedative, muscle relaxant
Medetomidine (R/S)	0.044 / 0.263	–		surgical anesthetic and analgesic
Medifoxamine	0.266	–		antidepressant
Medrysone	0.540	**	GR	synthetic corticosteroid used in ophthalmology
Mefenamic acid	0.393	*		NSAID
Mefenorex (R/S)	0.186 / 0.070	–		appetite suppressant
Mefloquine	0.295	–		antimalarial drug
Mefruside	0.373	*		treatment of edema and hypertension
Megestrol	0.531	**	PR	treatment of advanced breast/endometrium carcinoma
Meladrazine	0.161	–		antispasmodic used in urology
Melitracen	0.441	*		antidepressant
Meloxicam	0.115	–		NSAID
Melperone	0.412	*		antipsychotic drug
Melphalan (R/S)	0.224 / 0.316	*		chemotherapeutic drug
Menitrazepam	0.148	–		sedative, anticonvulsant, muscle relaxant, anxiolytic
Mephenesin (R/S)	0.346 / 0.302	–		muscle relaxant
Mephenoxalone (R/S)	0.222 / 0.240	*		anxiolytic drug
Mephenytoin (R/S)	0.115 / 0.066	–		anticonvulsant
Mephentermine	0.078	–		cardiac stimulant
Mepitiostane	0.511	**	ERα	anabolic steroid
Mepivacaine	0.101	–		local anesthetic
Mepixanox	0.371	*		respiratory stimulant
Meprobamate	0.069	–		anxiolytic drug
Meprotixol (R/S)	0.146 / 0.204	–		cough suppressant
Meprylcaine	0.214	–		local anesthetic
Meptazinol (R/S)	0.280 / 0.088	–		opioid analgesic used in obstetrics
Mepyramine	0.214	–		first-generation antihistamine
Mequinol	0.263	–		treatment of liver spots
Mequitazine	0.287	–		antihistamine
Mercaptopurine	0.086	–		immunosuppressive drug
Mesalazine	0.274	–		NSAID
Mesoridazine (R/S)	0.288 / 0.269	–		treatment of schizophrenia
Mestanolone	0.685	**	AR	17α-methylated version of DHT
Mesterolone	0.676	**	AR	orally applicable androgen (DHT derivative)
Mestranol	0.657	**	ERβ	oral contraceptive
Mesuximide (R/S)	0.048 / 0.132	–		anticonvulsant
Metaclazepam (R/S)	0.445 / 0.276	*		anxiolytic drug
Metamizole	0.168	–		NSAID; powerful painkiller, fewer reducer
Metaraminol	0.093	–		treatment of hypotension
Metaxalone (R/S)	0.311 / 0.354	*		muscle relaxant
Metenolone	0.646	**	AR	anabolic steroid
Methandriole	0.734	***	AR	anabolic steroid
Methcathinone (R/S)	0.226 / 0.165	–		psychoactive stimulant
Methapyrilene	0.314	*		antihistamine with sedative effects
Metharbital	0.289	–		anticonvulsant
Methazolamide	0.235	–		treatment of glaucoma
Methdilazine (R/S)	0.172 / 0.353	*		antihistamine
Methimazole	0.000	–		antithyroid drug
Methocarbamol (R/S)	0.105 / 0.193	–		treatment of muscle spasms
Methoxamine (RR/RS/SR/SS)	0.153 / 0.152 / 0.300 / 0.130	–		treatment of supraventicular tachycardia
Methotrexate	0.325	*		antifolate drug
Methoxsalen	0.264	*		treatment of psoriasis, eczema
Methoxyphedrine (R/S)	0.316 / 0.145	–		stimulant drug
Methoxyphenamine (R/S)	0.230/ 0.147	–		NSAID
Methyldopa	0.113	–		antihypertensive drug
Methylpentynol (R/S)	0.083 / 0.084	–		hypnotic/sedative with anticonvulsant effects
Methylphenobarbital (R/S)	0.456 / 0.093	–		sedative, anxiolytic, anticonvulsant
Methylprednisolone	0.434	*		treatment of bronchial inflammation or acute bronchitis
Methysergide	0.598	**	ERβ	treatment of migraine headaches
Meticrane	0.227	–		diuretic drug
Metirosine	0.146	–		antihypertensive drug
Metitepine (R/S)	0.359 / 0.196	*		antipsychotic drug
Metixene	0.402	*		anti-parkinson drug
Metizoline	0.137	–		nasal preparation
Metoclopramide	0.126	–		antiemetic drug
Metolazone (R/S)	0.495 / 0.542	**	MR	thiazide diuretic
Metyrapone	0.245	–		treatment of hypercortisolism
Mexiletine (R/S)	0.249 / 0.154	–		antiarrhythmic agent
Mianserin (R/S)	0.290 / 0.197	–		antidepressant with antihistaminic/hypnosedative effects
Mibolerone	0.745	***	AR	potent anabolic steroid
Miconazole	0.434	*		antifungal agent
Midazolam	0.164	–		anxiolytic, amnesic, hypnotic, anticonvulsant
Miglitol	0.159	–		antidiabetic drug
Miglustat	0.188	–		treatment of Type 1 Gaucher disease
Milnacipran	0.180	–		antidepressant
Milrinone	0.208	*		management of heart failure
Minaprine	0.564	**	ERα	antidepressant
Minaxolone	0.313	*		general anesthetic
Mirfentanil	0.000	–		analgesic (μ-opioid receptor antagonist)
Miroprofen (R/S)	0.117 / 0.102	–		NSAID
Misoprostol	0.492	*		prevention of NSAID-induced gastric ulcers; abortifacient
Mitiglinide	0.143	–		treatment of type-2 diabetes
Mitotane (R/S)	0.325 / 0.409	*		treatment of adrenocortical carcinoma
Mitoxantrone	0.000	–		antienoplastic agent
Mitozolomide	0.083	–		antienoplastic agent
Mivazerol	0.150	–		α-adrenergic agonist
Mizolastine	0.027	–		non-sedating antihistamine
Mizoribine	0.174	–		immunosuppressive drug
Mofebutazone (R/S)	0.193 / 0.084	–		treatment of joint and muscular pain
Mofezolac	0.373	*		NSAID
Molindone (R/S)	0.433 / 0.277	*		treatment of schizophrenia
Mometasone furoate	0.581	**	GR	treatment of eczema, psoriasis, hay fewer, asthma
Monatepil (R/S)	0.000 / 0.031	–		calcium channel blocker
Monobenzone	0.569	**	ERβ	topical drug for medical depigmentation
Morclofone	0.425	*		cough suppressant
Moricizine	0.349	*		antiarrhythmic drug
Morinamide	0.248	–		treatment of tuberculosis
Morniflumate	0.217	–		NSAID
Morpheridine	0.156	–		opioid analgesic drug
Morphine	0.158	–		opioid analgesic drug: neurotoxic
Mosapramine (R/S)	0.366 / 0.367	*		antipsychotic drug
Mosapride	0.458	*		treatment of irritable bowel syndrome
Moxastine	0.117	–		antihistamine
Moxaverine	0.413	*		treatment of gastrointestinal disorders
Moxisylyte	0.214	–		treatment of erectile dysfunction
Moxonidine	0.241	–		antihypertensive drug
Mozavaptan (R/S)	0.255 / 0.000	–		treatment of hyponatremia
Muzolimine (R/S)	0.096 / 0.225	–		diuretic drug
Mycophenolic acid	0.256	–		immunosuppressant drug
Nabilone	0.438	*		synthetic cannabinoid
Nabumetone	0.355	*		NSAID
Nadolol (R/S)	0.169 / 0.101	–		treatment of high blood pressure, migraine and chest pain
Nafamostat	0.097	–		anticoagulant
Naftifine	0.223	–		antifungal drug
Naftopidil (R/S)	0.292 / 0.249	–		treatment of high blood pressure
Nalbuphine	0.127	–		synthetic opioid (analgesic)
Nalidixic acid	0.317	*		bacteriostatic
Naloxone	0.148	–		treatment of opioid overdose
Naltrexone	0.095	–		management of alcohol/opioid dependence
Naphazoline	0.232	–		vasoconstrictor
Naproxen (R/S)	0.306 / 0.320	*		NSAID: gastrointestinal disturbances
Naratriptan	0.244	–		treatment of migraine headaches
Nateglinide	0.205	–		treatment of type 2 diabetes
Nealbarbital	0.527	**	PPARγ	sedative, hypnotic
Nebracetam (R/S)	0.207 / 0.143	–		antidepressant
Necopidem	0.372	*		sedative, anxiolytic
Nedocromil	0.302	*		treatment of asthma
Nefazodone	0.298	–		antidepressant; withdrawn
Nefiracetam	0.333	*		nootropic: testicular toxicity in rats
Nefopam (R/S)	0.236 / 0.305	*		analgesic drug
Neltenexine	0.306	*		mucolytic drug
Nepafenac	0.434	*		NSAID
Nepicastat	0.062	–		treatment of congestive heart failure
Nepinalone (R/S)	0.359 / 0.165	*		cough suppressant
Nerisopam	0.399	*		anxiolytic, neuroleptic
Neticonazole	0.266	–		antifungal drug
Nevirapine	0.054	–		treatment of HIV infections and AIDS
Nialamide	0.129	–		antidepressant
Niaprazine (R/S)	0.000 / 0.000	–		sedating antihistamine
Nicardipine (R/S)	0.408 / 0.189	*		treatment of high blood pressure and angina
Nicergoline	0.221	–		treatment of senile dementia
Niclosamide	0.451	*		anthelmintic drug (teniacide)
Nicorandil	0.050	–		treatment of angina
Nifedipine	0.193	–		calcium-channel blocker; antianginal: mild side effects
Nifekalant	0.031	–		anti-arrhythmic agent
Nifenazone	0.219	–		treatment of joint and muscular pain
Niflumic acid	0.442	*		treatment of joint and muscular pain
Nifuratel (R/S)	0.186 / 0.044	–		drug used in gynecology
Nifuroxazide	0.500	*		treatment of colitis and diarrhea
Nifurtimox (R/S)	0.047 / 0.065	–		treatment of Chagas disease and sleeping sickness
Nifurtoinol	0.421	*		treatment of urinary tract infections
Nifurzide	0.323	*		anti-infective agent
Nilutamide	0.215	–		treatment of prostate cancer
Nilvadipine (R/S)	0.137 / 0.283	–		calcium-channel blocker
Nimetazepam	0.339	*		powerful hypnotic drug
Nimodipine (R/S)	0.202 / 0.247	–		calcium-channel blocker
Nimorazole	0.148	–		antiinfective agent
Niperotidine (E/Z)	0.153 / 0.327	*		antihistamine
Niridazole	0.106	–		schistosomicide
Nisoxetine (R/S)	0.173 / 0.190	–		antidepressant
Nitazoxanide	0.126	–		antiprotozoal agent
Nitisinone	0.209	–		treatment of hereditary tyrosinemia type 1
Nitrazepam	0.490	*		powerful hypnotic drug
Nitroxoline	0.043	–		antibiotic drug
Nizofenone	0.000	–		psychostimulant, nootropic
Nocodazole	0.188	–		antienoplastic agent
Nolatrexed	0.429	*		thymidylate synthase inhibitor
Nonabine (RR/RS/SR/SS)	0.472 / 0.387 / 0.468 / 0.427	*		antiemetic drug
Norcodeine	0.206	–		opiate analogue
Nordazepam	0.346	*		anticonvulsant, anxiolytic, muscle relaxant, sedative
Norfenefrine (R/S)	0.169 / 0.082	–		cardiac stimulant
Norgestimate	0.478	*		hormonal contraceptive
Norgestrienone	0.616	**	ERβ	progestogen hormone
Normethadone	0.266	–		cough suppressant
Normorphine	0.254	–		major metabolite of morphine
Ocfentanil	0.233	–		opioid analgesic
Ocinaplon	0.411	*		anxiolytic drug
Octodrine (R/S)	0.142 / 0.121	–		stimulant drug
Olopatadine	0.162	–		antihistamine
Olprinone	0.209	–		cardiotonic agent
Olsalazine	0.419	*		treatment of inflammatory bowel disease
Oltipraz	0.000	–		schistosomicide
Omapatrilat	0.363	*		antihypertensive agent
Omoconazole	0.429	*		antifungal drug
Ondansetron (R/S)	0.450 / 0.260	*		antiemetic: few side effects
Opipramol	0.382	*		anxiolytic drug
Orciprenaline (R/S)	0.127 / 0.180	–		bronchodilator
Ormeloxifene	0.452	*		non-steroidal oral contraceptive
Ornidazole (R/S)	0.265 / 0.041	–		treatment of protozoan infections (poultry industry)
Orphenadrine (R/S)	0.260 / 0.310	*		anticholinergic drug
Oseltamivir (prodrug/drug)	0.126 / 0.056	–		antiviral drug: several adverse reactions
Oxabolone	0.567	**	AR	anabolic steroid
Oxaceprol	0.284	–		NSAID (treatment of osteoarthritis)
Oxametacin	0.626	**	AR	NSAID
Oxamniquine (R/S)	0.208 / 0.125	–		antihelmintic with schistosomicidal activity
Oxantel	0.228	–		antihelmintic
Oxaprotiline (R/S)	0.221 / 0.297	–		antidepressant
Oxaprozin	0.301	*		NSAID
Oxatomide	0.378	*		antihistamine
Oxazepam (R/S)	0.270 / 0.305	*		anxiolytic, anticonvulsant, sedative
Oxcarbazepine	0.394	*		anticonvulsant
Oxetorone	0.337	*		antimigraine agent
Oxibendazole	0.379	*		treatment of worm infestations in horses and pets
Oxiconazole	0.176	–		antifungal medication
Oxidopamine	0.084	–		dopamine derivative (neurotransmitter analogue)
Oxilorphan	0.208	–		opioid antagonist
Oxiracetam (R/S)	0.170 / 0.102	–		nootropic: safe compound, not toxic
Oxodipine	0.245	–		calcium channel blocker
Oxolamine	0.129	–		cough suppressant
Oxomemazine (R/S)	0.166 / 0.216	–		antihistamine
Oxpheneridine (R/S)	0.165 / 0.111	–		opioid analgesic
Oxprenolol (R/S)	0.243 / 0.148	–		treatment of angina pectoris
Oxybutynin (R/S)	0.166 / 0.064	–		anticholinergic medication
Oxycinchophen	0.260	–		antirheumatic agent
Oxyclozanide	0.298	–		antihelmintic agent
Oxycodone	0.127	–		opioid analgesic
Oxyfedrine (RR/RS/SR/SS)	0.222 / 0.158 / 0.118 / 0.237	–		vasodilator
Oxymetazoline	0.128	–		decongestant
Oxymorphone	0.046	–		semi-synthetic opioid analgesic
Oxypertine	0.264	–		antipsychotic
Oxyphenbutazone (R/S)	0.310 / 0.314	*		antiemetic: few side effects
Oxyphencyclimine (R/S)	0.078 / 0.197	–		antimuscarinic drug
Oxyphenisatine	0.520	**	ERβ	laxative
Ozagrel	0.465	*		improvement of motor coordination
Pagoclone (R/S)	0.214 / 0.166	–		anxiolytic drug
Paliperidone (R/S)	0.080 / 0.082	–		atypical antipsychotic
Palonosetron	0.234	–		treatment of chemotherapy-induced nausea and vomiting
Pamaquine (R/S)	0.000 / 0.074	–		treatment of malaria
Panadiplon	0.098	–		anxiolytic drug
Paracetamol	0.212	–		analgesic drug, antipyretic: non carcinogenic
Parahydroxyamphetamine (R/S)	0.255 / 0.158	–		nervous stimulant (alkaloid; occurs also in plants)
Paramethadione (R/S)	0.007 / 0.004	–		anticonvulsant
Paramethasone	0.587	**	GR	anti-inflammatory drug
Pargyline	0.000	–		antihypertensive drug
Pefloxacin	0.141	–		treatment of life-threatening bacterial infections
Pemirolast	0.160	–		anti-allergic drug
Pempidine	0.021	–		ganglionic blocker
Penbutolol (R/S)	0.261 / 0.320	*		treatment of high blood pressure
Penciclovir	0.186	–		treatment of herpes virus infections
Penicillamine	0.077	–		pharmaceutical chelator
Pentamidine	0.135	–		antimicrobal medication
Pentifylline	0.103	–		vasodilator
Pentoxifylline	0.142	–		treatment of intermittent claudication and vascular dementia
Pentoxyverine	0.117	–		cough suppressant
Pergolide	0.099	–		treatment of Parkinsons's disease
Perhexiline (R/S)	0.181 / 0.343	*		antianginal agent: frequent adverse effects
Periciazine	0.391	*		antipsychotic drug
Perospirone	0.242	–		antipsychotic drug
Perphenazine	0.269	–		antipsychotic drug
Pethidine	0.228	–		analgesic drug
Phanquinone	0.172	–		antiprotozoal agent
Phenacemide	0.261	–		anticonvulsant
Phenacetin	0.342	*		analgesic
Phenadoxone (R/S)	0.507 / 0.321	**	AR	opioid analgesic
Phenampromide (R/S)	0.247 / 0.140	–		opioid analgesic
Phenazone	0.071	–		analgesic: hepatotoxic
Phenazopyridine	0.304	*		local analgesic (urinary tract infections)
Phencyclidine	0.145	–		anesthetic agent: hallucinogenic/neurotoxic
Phenelzine	0.118	–		antidepressant drug
Pheneridine	0.310	*		opioid analgesic
Pheneturide (R/S)	0.461 / 0.167	*		anticonvulsant
Phenibut (R/S)	0.287 / 0.203	–		improvement of neurological functions: low toxicity
Phenindamine (R/S)	0.260 / 0.365	*		antihistamine
Phenindione	0.145	–		anticoagulant
Pheniprazine (R/S)	0.173 / 0.182	–		antidepressant
Pheniramine (R/S)	0.159 / 0.265	–		antihistamine
Phenobarbital	0.594	**	ERα	anticonvulsant
Phenoxybenzamine (R/S)	0.447 / 0.197	*		anti-hypertensive
Phenpentermine (R/S)	0.163 / 0.170	–		anorectic drug; acts also as diuretic
Phenprobamate	0.136	–		skeletal muscle relaxant
Phenprocoumon (R/S)	0.227 / 0.316	*		anticoagulant drug
Phenpromethamine (R/S)	0.152 / 0.175	–		stimulant drug (banned by the World Antidoping Agency)
Phensuximide (R/S)	0.111 / 0.143	–		anticonvulsant
Phentolamine	0.376	*		vasodilator
Phenylbutazone	0.284	–		antiepileptic: teratogen; possibly carcinogenic
Phenylephrine	0.108	–		decongestant
Phenylpiracetam (R/S)	0.282 / 0.183	–		nootropic: low toxicity
Phenyltoloxamine	0.107	–		antihistamine with sedative and analgesic effects
Phenytoin	0.420	*		antiepileptic: teratogen; possibly carcinogenic
Phetharbital	0.329	*		anticonvulsant, sedative
Pholcodine	0.145	–		opioid cough suppressant
Piberaline	0.296	–		stimulant and antidepressant
Picamilon	0.124	–		nicotinyl-GABA: low toxicity
Picenadol (R/S)	0.309 / 0.224	–		opioid analgesic
Pidotimod	0.230	–		immunostimulant
Pilocarpine	0.070	–		treatment of glaucoma, xerostomia
Pimethixene	0.302	*		treatment of hyperactivity, anxiety, sleep disorders
Pimobendan (R/S)	0.333 / 0.395	*		inotropic, vasodilator
Pimozide	0.060	–		antipsychotic drug
Pinacidil (R/S)	0.095 / 0.266	–		vasodilator
Pinazepam	0.467	*		anxiolytic, anticonvulsant, sedative, muscle relaxant
Pindolol (R/S)	0.095 / 0.146	–		treatment of angina pectoris and hypertension
Pipazetate	0.207	–		cough suppressant
Pipequaline	0.377	*		anxiolytic drug
Piperidolate (R/S)	0.031 / 0.372	*		antimuscarinic drug
Piperocaine (R/S)	0.297 / 0.334	*		local anesthetic
Pipradrol	0.102	–		CNS stimulant
Piracetam	0.013	–		nootropic, dietary supplement: only mild side-effects
Pirbuterol (R/S)	0.092 / 0.021	–		treatment of asthma
Pirenzepine	0.224	–		treatment of peptic ulcers
Piretanide	0.093	–		diuretic
Piribedil	0.332	*		treatment of Parkinson's disease
Pirlindole (R/S)	0.333 / 0.307	*		antidepressant
Pirisudanol	0.065	–		psychostimulant
Piroheptine (R/S)	0.349 / 0.314	*		treatment of Parkinson's disease
Piroxicam	0.008	–		NSAID
Pirprofen (R/S)	0.261 / 0.260	–		NSAID
Pizotifen	0.330	*		treatment of migraine headaches
Pleconaril	0.223	–		antiviral drug (asthma)
Polythiazide (R/S)	0.415 / 0.146	*		diuretic
Practolol (R/S)	0.105 / 0.165	–		treatment of cardiac arrhythmias
Pramipexole	0.009	–		treatment of Parkinson's disease
Pramiracetam	0.000	–		nootropic: safe compound
Pranoprofen (R/S)	0.257 / 0.423	*		NSAID
Pravadoline	0.416	*		NSAID
Prazepam	0.354	*		anxiolytic, anticonvulsant, sedative
Praziquantel	0.206	–		anthelmintic effective against flatworms
Prazosin	0.234	–		antihypertensive: some side effects
Prednicarbate	0.437	*		topical corticosteroid
Prednisolone	0.427	*		active metabolite of Prednisone (treatment of inflammation and AID)
Prednisone	0.419	*		synthetic corticosteroid drug
Pridinol	0.236	–		muscle relaxant
Prilocaine (R/S)	0.005 / 0.192	–		local anesthetic
Procarbazine	0.301	*		antienoplastic agent
Prodine (αax/αeq/βax/βeq)	0.090 / 0.203 / 0.094 / 0.210	–		opioid analgesic
Profenamine (R/S)	0.131 / 0.000	–		treatment of Parkinson's disease
Proguanil	0.177	–		prophylactic antimalarial drug
Promethazine (R/S)	0.251 / 0.109	–		antihistamine, antiemetic, sedative
Propafenone (R/S)	0.376 / 0.230	*		anti-arrhythmic medication
Propofol	0.133	–		anesthesia agent
Propranolol (R/S)	0.121 / 0.120	–		treatment of hypertension
Propylthiouracil	0.303	*		treatment of hyperthyroidism
Pseudoephedrine	0.149	–		decongestant
Pyrantel	0.118	–		antinematodal agent
Pyrithyldione	0.098	–		hypnotic, sedative
Pyritinol	0.050	–		treatment of chronically impaired brain function
Pyrovalerone (R/S)	0.225 / 0.031	–		stimulant drug (fatigue, lethargy); appetite suppressant
Quazepam	0.075	–		treatment of insomnia
Quinbolone	0.597	**	AR	anabolic steroid
Quinethazone (R/S)	0.211 / 0.311	*		treatment of hypertension
Quinestrol	0.527	**	ERβ	treatment of breast and prostate cancer
Quinidine	0.235	–		antiarrhythmic agent
Quinisocaine	0.000	–		antipruritic agent
Quinpirole	0.060	–		dopamine D2/D3 receptor agonist
Quipazine	0.263	–		serotonin receptor agonist (5HT2A,, 5HT3)
Rabeprazole	0.423	*		proton pump inhibitor
Racecadotril (R/S)	0.123 / 0.210	–		antidiarrheal drug
Raclopride	0.184	–		neuroleptic (treatment of schizophrenia)
Rafoxanide	0.190	–		antiparasitic agent
Ramatroban	0.448	*		treatment of coronary artery disease
Ramipril	0.151	–		treatment of hypertension
Ramosetron	0.400	–		treatment of nausea an vomiting
Ranitidine	0.045	–		treatment of peptic ulcer disease
Ranolazine (R/S)	0.221 / 0.273	–		antianginal medication
Rasagiline	0.106	–		irreversible MAO inhibitor: safe; possible drug interactions
Razobazam	0.149	–		produces nootropic effects
Rebamipide (R/S)	0.457 / 0.190	*		treatment of Behçet's disease
Reclazepam	0.436	*		sedative, anxiolytic
Remacemide (R/S)	0.358 / 0.275	*		sodium channel blocker
Remoxipride	0.244	–		antipsychotic drug
Rentiapril	0.308	*		ACE inhibitor
Renzapride	0.258	–		treatment of irritable bowel syndrome
Repirinast	0.165	–		antihistamine
Ribavirin	0.318	*		antiviral drug
Rilmazafone	0.234	–		sedative, hypnotic
Rilmenidine	0.232	–		treatment of hypertension
Riluzole	0.194	–		treatment of amyotrophic lateral sclerosis
Rimantadine (R/S)	0.260 / 0.207	–		antiviral drug
Rimcazole	0.355	*		anticonvulsant
Rimexolone	0.427	*		treatment of inflammation in the eye
Rimiterol	0.064	–		third-generation β2 agonist
Rimonabant	0.206	–		anti-obesity drug (temporarily withdrawn from market)
Ripazepam	0.272	–		anxiolytic
Risocaine	0.125	–		local anesthetic
Ritanserin	0.443	*		treatment of schizophrenia
Ritodrine	0.421	*		tocolytic drug
Rivastigmine	0.221	–		treatment of dementia (Alzheimer and due to Parkinson's disease)
Rizatriptan	0.096	–		treatment of migraine headaches
Robalzotan	0.258	–		potential antidepressant
Robenidine	0.137	–		coccidiostat
Rociverine (R/S)	0.000 / 0.106	–		antimuscarinic
Roflumilast	0.477	*		treatment of inflammatory diseases of the lungs
Rolicyclidine	0.015	–		anesthetic, hallucinogenic, sedative
Rolipram (R/S)	0.425 / 0.453	*		NSAID
Rolziracetam	0.125	–		nootropic drug
Romifidine	0.221	–		sedative, anesthetic, analgesic (veterinary medicine)
Ronifibrate	0.199	–		fibrate
Ropinirole	0.018	–		treatment of Parkinson's disease
Ropivacaine	0.228	–		local anesthetic
Roquinimex	0.150	–		immunostimulant
Rosiglitazone (R/S)	0.539 / 0.440	**	PPARγ	anti-diabetic drug
Rosoxacin	0.320	–		treatment of urinary tract infections
Rubitecan	0.128	–		oral topoisomerase inhibitor (withdrawn)
Rufinamide	0.301	*		anticonvulsant medication
Rupatadine	0.433	*		antihistamine
Salbutamol (R/S)	0.104 / 0.048	–		treatment of asthma and COPD
Salicylamide	0.080	–		analgesic and antipyretic properties
Salsalate	0.269	–		NSAID
Saripidem	0.262	–		sedative, anxiolytic
Sarmazenil	0.081	–		anxiogenic, convulsant (veterinary medicine)
Sarpogrelate (R/S)	0.339 / 0.202	–		treatment of many diseases (e.g. diabetes mellitus)
Secnidazole (R/S)	0.094 / 0.158	–		anti-infective drug
Selegiline	0.130	–		treatment of Parkinson's disease, depression and senile dementia
Selfotel	0.356	*		anticonvulsant, anxiolytic, analgesic
Sematilide	0.000	–		antiarrhythmic agent
Seratrodast (R/S)	0.459 / 0.550	**	TRα	treatment of asthma
Sertaconazole (R/S)	0.493 / 0.357	*		antifungal medication
Sertindole	0.000	–		treatment of schizophrenia
Setastine (R/S)	0.329/ 0.325	*		antihistamine
Setiptiline	0.363	*		antidepressant
Sibutramine (R/S)	0.000 / 0.000	–		appetite suppressant
Simfibrate	0.289	–		fibrate
Sivelestat	0.000	–		treatment of acute respiratory failure
Sofalcone	0.133	–		oral gastrointestinal medication
Solabegron	0.048	–		treatment of overactive bladder and irritable bowel syndrome
Sorivudine	0.176	–		antiviral drug
Sotalol (R/S)	0.177 / 0.008	–		treatment of cardiac arrhythmias
Spiperone	0.203	–		antipsychotic drug
Spiradoline	0.101	–		analgesic, diuretic, antitussive
Spironolactone	0.373	–		diuretic, antiandrogen
Stavudine	0.224	–		reverse transcriptase inhibitor
Stepronin (R/S)	0.319 / 0.129	*		mucolytic
Stiripentol (R/S)	0.440 / 0.437	*		treatment of epilepsy
Styramate (R/S)	0.153 / 0.143	–		muscle relaxant, anticonvulsant
Sulconazole (R/S)	0.430 / 0.408	*		antifungal medication
Sufentanil	0.350	*		opioid analgesic drug
Sulazepam	0.080	–		sedative, muscle relaxant, hypnotic, anticonvulsant, anxiolytic
Sulbentine	0.045	–		antifungal agent
Sulfadiazine	0.171	–		sulfonamide antibiotic
Sulfadimethoxine	0.215	–		sulfonamide antibiotic
Sulfadimidine	0.051	–		sulfonamide antibiotic
Sulfadoxine	0.115	–		ultra-long lasting sulfonamide (malaria)
Sulfafurazole	0.152	–		sulfonamide antibiotic
Sulfalene	0.098	–		sulfonamide antibiotic
Sulfamerazine	0.026	–		sulfonamide antibiotic
Sulfamethizole	0.273	–		sulfonamide antibiotic
Sulfamethoxypyridazine	0.173	–		sulfonamide antibiotic
Sulfametomidine	0.055	–		sulfonamide antibiotic
Sulfametoxydiazine	0.167	–		sulfonamide antibiotic (leprae, urinary tract infections)
Sulfametrole	0.099	–		sulfonamide antibiotic
Sulfamoxole	0.072	–		sulfonamide antibiotic
Sulfaperin	0.102	–		sulfonamide antibiotic
Sulfaphenazole	0.162	–		sulfonamide antibiotic
Sulfapyridine	0.237	–		antibacterial drug
Sulfasalazine	0.205	–		treatment of inflammatory bowel disease
Sulfathiazole	0.307	*		short-acting sulfa drug
Sulfinpyrazone	0.149	–		treatment of gout
Sulfisomidine	0.013	–		sulfonamide antibiotic
Sulforidazine (R/S)	0.450 / 0.000	*		antipsychotic drug
Sulindac	0.278	–		NSAID for acute or chronic inflammations
Sulpiride (R/S)	0.217 / 0.099	–		treatment of schizophrenia and depression
Sultiame	0.237	–		anticonvulsant
Sumatriptan	0.118	–		treatment of migraine headaches
Suproclone (R/S)	0.000 / 0.000	–		sedative, anxiolytic
Suprofen (R/S)	0.338 / 0.203	*		NSAID
Suriclone (R/S)	0.152 / 0.157	–		sedative, anxiolytic
Suritozole	0.017	–		cognition enhancer (investigational)
Suxibuzone	0.222	–		treatment of joint and muscular paint
Tacalcitol	0.233	–		treatment of psoriasis
Tacrine	0.139	–		treatment of Alzheimer's disease
Talastine	0.239	–		antihistamine
Talbutal (R/S)	0.424 / 0.455	*		short to intermediate-acting barbiturate
Talipexole	0.110	–		treatment of Parkinsons's disease
Talopram (R/S)	0.291 / 0.296	*		antidepressant
Tamoxifen	0.223	–		selective estrogen receptor modulator: carcinogenic, thromboembolism
Tasosartan	0.128	–		angiotensin II receptor antagonist
Tazarotene	0.333	*		treatment of psoriasis, acne and sun-damaged skin
Teclozan	0.237	–		antiprotozoal agent
Tedisamil	0.000	–		antiarrhythmic for atrial fibration and flutter
Tegafur (R/S)	0.356 / 0.363	*		treatment of cancer (prodrug)
Temozolomide	0.091	–		treatment of astrocytoma (brain tumor)
Tenidap	0.156	–		NSAID
Tenonitrozole	0.135	–		antiprotozoal agent
Tenoxicam	0.011	–		NSAID
Tepoxalin	0.293	–		NSAID
Terazosin (R/S)	0.165 / 0.245	–		treatment of hypertension along with BPH
Terbinafine	0.411	*		antifungal drug
Terbutaline (R/S)	0.000 / 0.019	–		bronchodilator
Terizidone (RR/RS=SR/SS)	0.289 / 0.447 / 0.424	*		treatment of tuberculosis
Terodiline (R/S)	0.355 / 0.375	*		antispasmodic drug used in urology
Tertatolol (R/S)	0.138 / 0.182	–		treatment of hypertension
Tetrabenazine	0.233	–		treatment of hyperkinetic movement disorder
Tetracaine	0.103	–		local anesthetic
Tetrahydrozoline (R/S)	0.132 / 0.112	–		vasoconstrictor (eye drops, nasal sprays): toxic at over dosage
Tetrazepam	0.243	–		anxiolytic, muscle relaxant
Thenalidine	0.256	–		antipuritic drug
Thenyldiamine	0.149	–		antihistamine
Theodrenaline (R/S)	0.158 / 0.000	–		cardiac stimulant
Theophylline	0.034	–		treatment of COPD, Asthma: toxic by interaction with other drugs
Thialbarbital	0.000	–		sedative drug
Thiamphenicol	0.056	–		veterinary antibiotic
Thiethylperazine	0.354	*		treatment of nausea and vomiting
Thioacetazone	0.344	*		treatment of tuberculosis
Thiocarlide	0.091	–		treatment of tuberculosis
Thioguanine	0.050	–		treatment of cancer (antimetabolite)
Thioridazine (R/S)	0.306 / 0.336	*		treatment of schizophrenia and psychosis
Thonzylamine	0.097	–		antihistamine, antipuritic
Tiagabine	0.263	–		anticonvulsive medication
Tianeptine (R/S)	0.216 / 0.296	–		antidepressant, anxiolytic
Tiapride	0.304	*		neuroleptic agent
Tiaprofenic acid (R/S)	0.416 / 0.310	*		NSAID
Tibolone	0.628	**	ERβ, PR	hormone-replacement therapeutic
Ticlatone	0.141	–		antifungal agent
Ticlopidine	0.077	–		antiplatelet drug
Tidiacic (RR/RS/SR/SS)	0.171 / 0.406 / 0.161 / 0.320	*		hepatoprotective drug
Tiflorex (R/S)	0.274 / 0.164	–		appetite suppressant
Tifluadom (R/S)	0.214 / 0.215	–		analgesic, diuretic, sedative, appetite stimulant
Tilbroquinol	0.266	–		antiprotozoal agent
Tiletamine (R/S)	0.049 / 0.000	–		dissociative anesthetic (veterinary medicine)
Tilisolol (R/S)	0.186 / 0.262	–		treatment of hypertension and angina pectoris
Tilorone	0.000	–		orally active interferon inducer
Timiperone	0.148	–		neuroleptic drug
Timolol	0.076	–		treatment of high blood pressure
Tioconazole (R/S)	0.225 / 0.423	*		antifungal medication
Tipepidine	0.086	–		cough suppressant
Tiratricol	0.576	**	TRα	thyroid hormone analogue
Tirofiban	0.000	–		antiplatelet drug
Tiropramide (R/S)	0.000 / 0.360	*		antispasmodic
Tisopurine	0.000	–		treatment of gout
Tixocortol	0.470	*		intestinal anti-inflammatory and decongestant
Tizanidine	0.117	–		muscle relaxant
Tocainide (R/S)	0.263 / 0.188	–		antiarrhythmic agent
Tofisopam (R/S)	0.457 / 0.216	*		anxiolytic drug: not approved in US/Canada
Tolazamide	0.218	–		oral blood-glucose lowering drug (type-2 diabetes)
Tolazoline	0.060	–		vasodilator; treatment of acrocyanosis
Tolbutamide	0.210	–		management of type-2 diabetes
Tolcapone	0.114	–		treatment of Parkinson's disease; hepatotoxic
Tolciclate	0.272	–		antifungal medication
Tolfenamic acid	0.074	–		NSAID
Tolmetin	0.111	–		treatment of arthritis: several side effects; toxic to rats
Tolnaftate	0.248	–		over-the-counter antifungal agent
Toloxatone (R/S)	0.369 / 0.441	*		antidepressant
Tolperisone (R/S)	0.005 / 0.101	–		muscle relaxant
Tolpropamine (R/S)	0.311 / 0.243	*		antihistamine used as an antipruritic
Toltrazuril	0.079	–		coccidiostat
Topotecan	0.000	–		chemotherapy agent: some side effects
Torasemide	0.167	–		loop diuretic
Toremifene	0.056	–		selective estrogen receptor modulator
Tracazolate	0.000	–		anxiolytic drug
Tramadol	0.053	–		analgesic
Tramazoline	0.263	–		nasal preparation
Tranexamic acid	0.390	*		antifibrinolytic agent
Tranilast	0.420	–		antiallergic drug
Tranylcypromine	0.087	–		antidepressant
Trapidil	0.000	–		vasodilator
Trefentanil	0.069	–		opioid analgesic
Trepibutone	0.031	–		treatment of gastrointestinal disorders
Trestolone	0.708	***	AR	hormonal male contraceptive
Triamcinolone	0.452	*		treatment of rhinoplasy and severe hay fewer
Triamterene	0.098	–		potassium-sparing diuretic
Triapine	0.178	–		under investigation for cancer treatment
Triclabendazole	0.410	*		antihelminthic
Trichlormethiazide (R/S)	0.227 / 0.336	*		treatment of edema
Triethylenemelamine	0.000	–		drug used in chemotherapy
Triflubazam	0.155	–		sedative, anxiolytic
Trifluoperazine	0.326	*		treatment of schizophrenia
Trifluperidol	0.247	–		antipsychotic drug (mania, schizophrenia)
Triflupromazine	0.301	*		antipsychotic drug
Trifluridine	0.197	–		antiviral drug (herpes)
Triflusal	0.280	–		platelet-aggregation inhibitor
Trihexyphenidyl (R/S)	0.026 / 0.000	–		antiparkinsonian drug
Trilostane	0.543	**	ERα	treatment of Cushing's syndrome
Trimazosin	0.264	–		sympatholytic drug
Trimebutine (R/S)	0.350 / 0.359	*		antimuscarinic
Trimecaine	0.000	–		local anesthetic
Trimetazidine	0.179	–		treatment of angina pectoris
Trimethadione	0.041	–		anticonvulsant
Trimethobenzamide	0.189	–		antiemetic (prevention of nausea and vomiting)
Trimetozine	0.201	–		anxiolytic drug
Trimetrexate	0.107	–		treatment of pneumocystis pneumonia
Tripelennamine	0.275	–		antipruritic and antihistamine
Triprolidine	0.350	*		over-the-counter antihistamine
Tritoqualine (RR/RS/SR/SS)	0.369 / 0.213 / 0.429 / 0.471	*		antihistamine
Tropatepine	0.329	*		anti-parkinson drug
Tropicamide (R/S)	0.098 / 0.132	–		parasympatholytic (used for eye examinations)
Troxipide (R/S)	0.092 / 0.180	–		treatment of gastroesophageal reflux disease
Tulobuterol (R/S)	0.128 / 0.112	–		β2-adrenergic receptor agonist
Ufenamate	0.005	–		topical analgesic
Uldazepam	0.268	–		sedative, anxiolytic
Ulobetasol	0.448	*		corticosteroid
Uramustine	0.169	–		chemotherapeutic drug
Urapidil	0.099	–		sympatholytic drug
Valdecoxib	0.408	*		treatment of osteoarthritis and rheumatoid arthritis
Valnoctamide (RR/RS/SR/SS)	0.145 / 0.124 / 0.092 / 0.000	–		sedative, hypnotic
Valofane (RR/RS/SR/SS)	0.151 / 0.336 / 0.042 / 0.037	*		sedative drug
Valproic acid	0.039	–		anticonvulsant
Valpromide	0.083	–		treatment of epilepsy
Valsartan	0.041	–		treatment of hypertension
Vanoxerine	0.310	*		treatment of cocaine dependence
Varenicline	0.254	–		treatment of smoking addiction
Vedaclidine (R/S)	0.153 / 0.209	–		analgesic drug
Vernakalant	0.218	–		investigational drug (atrial fibrillation)
Vesnarinone	0.371	*		cardiotonic agent
Vigabatrin (R/S)	0.291 / 0.413	*		anticonvulsant
Viloxazine (R/S)	0.145 / 0.156	–		antidepressant
Viminol (six isomers)	0.044–0.227	–		opioid analgesic
Vinburnine	0.056	–		vasodilator
Vinconate	0.095	–		nootropic
Vinpocetine	0.262	–		nootropic, neuroprotective: no adverse reactions reported
Voglibose	0.000	–		treatment of diabetes mellitus
Voriconazole	0.001	–		antifungal medication
Vorinostat	0.323	*		treatment of cutaneous T cell lymphoma
Vorozole (R/S)	0.000 / 0.082	–		antienoplastic agent
Xaliproden	0.340	*		treatment of Alzheimer's disease
Xamoterol (R/S)	0.111 / 0.185	–		cardiac stimulant
Xanomeline	0.151	–		nasal decongestant
Xipamide	0.206	–		diuretic drug
Xorphanol	0.396	*		opioid analgesic
Xylazine	0.252	–		sedative, anesthetic, muscle relaxant, analgesic (veterinary medicine)
Xylometazoline	0.181	–		treatment of Alzheimer's disease and schizophrenia
Zacopride (R/S)	0.169 / 0.230	–		anxiolytic, nootropic, antiemetic
Zalcitabine	0.130	–		reverse transcriptase inhibitor
Zaleplon	0.339	*		sedative, hypnotic
Zalospirone	0.040	–		antidepressant
Zanamivir	0.109	–		neuroamidase inhibitor
Zapizolam	0.318	*		sedative, anxiolytic
Zatosetron	0.000	–		antinauseant, anxiolytic
Zidovudine	0.171	–		treatment of HIV
Zileuton (R/S)	0.275 / 0.116	–		treatment of asthma
Zinterol (R/S)	0.000 / 0.000	–		β-adrenergic agonist
Ziprasidone	0.109	–		atypical antipsychotic drug
Zofenopril	0.172	–		treatment of hypertension
Zolazepam	0.143	–		veterinary anesthetic
Zolmitriptan	0.157	–		treatment of migraine
Zolpidem	0.202	–		treatment of insomnia; anticonvulsant, muscle relaxant
Zomepirac	0.392	*		antipyretic (withdrawn from market)
Zonisamide	0.217	–		anticonvulsant
Zopiclone (R/S)	0.284 / 0.197	–		treatment of insomnia
Zotepine	0.272	–		treatment of schizophrenia
Zuclopenthixol	0.000	–		antipsychotic neuroleptic drug
Zylofuramine	0.059	–		appetite suppressant (never marketed)